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Sema3dtm1a(KOMP)Bzsh
Targeted Allele Detail
Nomenclature
Symbol: Sema3dtm1a(KOMP)Bzsh
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; targeted mutation 1a, Bin Zhou
MGI ID: MGI:5638222
Synonyms: Sema3dLacz
Gene: Sema3d  Location: Chr5:12383385-12588948 bp, + strand  Genetic Position: Chr5, 3.97 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220957
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 12505357 of Chromosome 5 upstream of the critical exon 5 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 5 at position 12506136. The critical exon 5 is thus flanked by loxP sites. (J:220957)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema3d Mutation:  3 strains or lines available
References
Original:  J:220957 Tian X, et al., Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res. 2013 Sep;23(9):1075-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory