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Targeted Allele Detail
Symbol: Apptm1.1Tcs
Name: amyloid beta (A4) precursor protein; targeted mutation 1.1, Takaomi C Saido
MGI ID: MGI:5637815
Synonyms: AppNL
Gene: App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Germline Transmission:  Earliest citation of germline transmission: J:212758
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
Mutation detailsThe sequence of exon 16 was humanized and the Swedish mutations (KM670/671NL) were introduced and a floxed neo cassette was inserted in intron 16 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:212758)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  68 strains or lines available
Original:  J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory