Abcb5^tm1.1Nyf
Targeted Allele Detail

Summary

• Symbol: Abcb5^tm1.1Nyf
• Name: ATP-binding cassette, sub-family B member 5; targeted mutation 1.1, Natasha Y Frank
• MGI ID: MGI:5637592
• Synonyms: Abcb5^loxP
• Gene: Abcb5 Location: Chr12:118831559-118930156 bp, - strand Genetic Position: Chr12, 63.48 cM, cytoband F2
• Alliance: Abcb5^tm1.1Nyf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213708
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 458 bp upstream of exon 10 and an FRT flanked neo cassette and loxP site were inserted 460 bp downstream of exon 10 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:213708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcb5 Mutation: 81 strains or lines available

References

• Original: J:213708 Ksander BR, et al., ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17;511(7509):353-7
• All: 1 reference(s)