Orai1^tm1.2Hjm
Targeted Allele Detail

Summary

• Symbol: Orai1^tm1.2Hjm
• Name: ORAI calcium release-activated calcium modulator 1; targeted mutation 1.2, Helen J McBride
• MGI ID: MGI:5637539
• Synonyms: Orai1^-
• Gene: Orai1 Location: Chr5:123153137-123168519 bp, + strand Genetic Position: Chr5, 62.72 cM
• Alliance: Orai1^tm1.2Hjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 about 1 kb upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted about 0.3 kb 3' of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 2 and 3. (J:212535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Orai1 Mutation: 22 strains or lines available

References

• Original: J:212535 Somasundaram A, et al., Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells. J Neurosci. 2014 Jul 2;34(27):9107-23
• All: 2 reference(s)