Ccna2^tm1.2Kald
Targeted Allele Detail

Summary

• Symbol: Ccna2^tm1.2Kald
• Name: cyclin A2; targeted mutation 1.2, Philipp Kaldis
• MGI ID: MGI:5637532
• Synonyms: A2^-
• Gene: Ccna2 Location: Chr3:36619014-36626299 bp, - strand Genetic Position: Chr3, 17.67 cM
• Alliance: Ccna2^tm1.2Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212546
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 3 - 5. (J:212546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccna2 Mutation: 13 strains or lines available

References

• Original: J:212546 Gopinathan L, et al., Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res. 2014 Jul 15;74(14):3870-9
• All: 1 reference(s)