Hcrtr1^tm1.2Ava
Targeted Allele Detail

Summary

• Symbol: Hcrtr1^tm1.2Ava
• Name: hypocretin (orexin) receptor 1; targeted mutation 1.2, Anne Vassalli
• MGI ID: MGI:5637401
• Synonyms: Hcrtr1^delta-GFP
• Gene: Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
• Alliance: Hcrtr1^tm1.2Ava page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226158
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted at the start codon in exon 3. A loxP site, GFP reporter gene, polyadenylation sequence, and FRT-flanked neomycin resistance cassette were inserted into intron 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the coding sequence in exon 3, intron 3 and exon 4. (J:226158)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcrtr1 Mutation: 32 strains or lines available

References

• Original: J:226158 Vassalli A, et al., Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children? Comment on Antibodies to influenza nucleoprotein cross react with human hypocretin receptor 2. Sci Transl Med. 2015;7:314le2
• All: 3 reference(s)