Hcrtr1tm1.2Ava
Targeted Allele Detail
|
Symbol: |
Hcrtr1tm1.2Ava |
Name: |
hypocretin (orexin) receptor 1; targeted mutation 1.2, Anne Vassalli |
MGI ID: |
MGI:5637401 |
Synonyms: |
Hcrtr1delta-GFP |
Gene: |
Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
|
Alliance: |
Hcrtr1tm1.2Ava page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:226158
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
C57BL/6NTac
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted at the start codon in exon 3. A loxP site, GFP reporter gene, polyadenylation sequence, and FRT-flanked neomycin resistance cassette were inserted into intron 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the coding sequence in exon 3, intron 3 and exon 4.
(J:226158)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Hcrtr1 Mutation: |
32 strains or lines available
|
|
Original: |
J:226158 Vassalli A, et al., Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children? Comment on Antibodies to influenza nucleoprotein cross react with human hypocretin receptor 2. Sci Transl Med. 2015;7:314le2 |
All: |
3 reference(s) |
|