Hcrtr1^tm1.1Ava
Targeted Allele Detail

Summary

• Symbol: Hcrtr1^tm1.1Ava
• Name: hypocretin (orexin) receptor 1; targeted mutation 1.1, Anne Vassalli
• MGI ID: MGI:5637400
• Synonyms: Hcrtr1^flox
• Gene: Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
• Alliance: Hcrtr1^tm1.1Ava page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226158
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site was inserted at the start codon in exon 3. A loxP site, GFP reporter gene, polyadenylation sequence, and FRT-flanked neomycin resistance cassette were inserted into intron 4. Flp-mediated recombination removed the selection cassette. (J:226158)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcrtr1 Mutation: 32 strains or lines available

References

• Original: J:226158 Vassalli A, et al., Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children? Comment on Antibodies to influenza nucleoprotein cross react with human hypocretin receptor 2. Sci Transl Med. 2015;7:314le2
• All: 3 reference(s)