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Chd1tm1b(KOMP)Rsan
Targeted Allele Detail
Nomenclature
Symbol: Chd1tm1b(KOMP)Rsan
Name: chromodomain helicase DNA binding protein 1; targeted mutation 1b, Miguel Ramalho-Santos
MGI ID: MGI:5637386
Gene: Chd1  Location: Chr17:15704967-15772610 bp, + strand  Genetic Position: Chr17, 8.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217689
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 15741674 of Chromosome 17 upstream of the critical exon 16 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 16 at position 15742567. The critical exon 16 is thus flanked by loxP sites. A knock-out allele was created by cre recombinase expression in ES cells carrying this allele. (J:217689)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chd1 Mutation:  15 strains or lines available
References
Original:  J:217689 Guzman-Ayala M, et al., Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory