Pax3^{tm7(Notch1*)Buck}
Targeted Allele Detail

Summary

• Symbol: Pax3^{tm7(Notch1*)Buck}
• Name: paired box 3; targeted mutation 7, Margaret E Buckingham
• MGI ID: MGI:5636809
• Synonyms: Pax3^{AP(NICD-IRESnLacZ)}
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^{tm7(Notch1*)Buck} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Pax3^{tm7(Notch1*)Buck} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: A floxed puro resistance cassette and sequence encoding the activated intracellular domain of mouse Notch1 and an IRES nlacZ were inserted into exon 1 via homologous recombination. (J:212088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 51 strains or lines available

References

• Original: J:212088 Mayeuf-Louchart A, et al., Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8844-9
• All: 1 reference(s)