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QTL Variant Detail
QTL variant: Jckm1C57BL/6J
Name: juvenile cystic kidney modifier 1; C57BL/6J
MGI ID: MGI:5636758
QTL: Jckm1  Location: Chr10:118661259-120899582 bp  Genetic Position: Chr10, cM position of peak correlated region/allele: 34.83 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Jckm1 was mapped between D10Mit14 and D10Mit102 on mouse Chromosome 10 using 55 F2 progeny from the (C57BL/6J x DBA/2J)F1 jck /+ intercross and quantitative trait locus analysis. The LOD score for placing Jckm1 in the region bewteen D1Mit14 and D10Mit102is 2.0.


(C57BL/6J x DBA/2J)F2-jck/+ intercross animals were used to map QTLs that modify the severity of polycystic kidney disease (PKD). The parental C57BL/6J strain used in this cross carries a homozygous mutation in the jck gene resulting in enhanced PKD phenotype (increased kidney weight). DBA/2J is wild type at the jck locus and exhibits a mild PKD phenotype. Jckm1 (juvenile cystic kidney modifier 1) mapped to chromosome 10 with a peak LOD score of 2.1 between D10Mit14 (65 cM) and D10Mit102 (69 cM). DBA/2J-derived alleles at this locus appear to increase PKD severity in an additive fashion. Jckm2 mapped to chromosome 1 with a peak LOD score of 16.8 between D1Mit7 (41 cM) and D1Mit30 (70 cM). C57BL/6J-derived alleles confer recessively inherited susceptibility to PKD at this locus. There appears to be strain-specific interactions between Jckm1 and Jckm2: animals homozygous for C57BL/6J-like alleles at Jckm2 and homozygous for DBA/2J-like alleles at Jckm1 develop severe PKD.

Original:  J:23893 Iakoubova OA, et al., Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity. Genomics. 1995 Mar 1;26(1):107-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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