Srpk1^tm1.1Xdfu
Targeted Allele Detail

Summary

• Symbol: Srpk1^tm1.1Xdfu
• Name: serine/arginine-rich protein specific kinase 1; targeted mutation 1.1, Xiang-Dong Fu
• MGI ID: MGI:5636749
• Gene: Srpk1 Location: Chr17:28806622-28841683 bp, - strand Genetic Position: Chr17, 14.78 cM
• Alliance: Srpk1^tm1.1Xdfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance selection cassette with a 5' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:213142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srpk1 Mutation: 46 strains or lines available

References

• Original: J:213142 Wang P, et al., Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 8;54(3):378-91
• All: 1 reference(s)