Casp1^tm2.1Flv
Targeted Allele Detail

Summary

• Symbol: Casp1^tm2.1Flv
• Name: caspase 1; targeted mutation 2.1, Richard Flavell
• MGI ID: MGI:5636721
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^tm2.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211694
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were floxed and an Frt and loxP flanked neo cassette were inserted via homologous recombination. Cre mediated recombination deleted the floxed region. (J:211694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 41 strains or lines available

References

• Original: J:211694 Case CL, et al., Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6
• All: 4 reference(s)