Map3k8^tm2.1Sley
Targeted Allele Detail

Summary

• Symbol: Map3k8^tm2.1Sley
• Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 2.1, Steven C Ley
• MGI ID: MGI:5636697
• Synonyms: Map3k8^S400A
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^tm2.1Sley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211623
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted into intron 5 and an S400A mutation was inserted into exon 7 via homologous recombination. Cre mediated recombination removed the neo cassette. Mutant protein expression is similar to wild-type but activation of ERK-1/2 following LPS stimulation is blocked. (J:211623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 44 strains or lines available

References

• Original: J:211623 Ben-Addi A, et al., IkappaB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403
• All: 1 reference(s)