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Zbtb46tm1.1Kmm
Targeted Allele Detail
Nomenclature
Symbol: Zbtb46tm1.1Kmm
Name: zinc finger and BTB domain containing 46; targeted mutation 1.1, Kenneth Murphy
MGI ID: MGI:5636376
Synonyms: Zbtb46GFP
Gene: Zbtb46  Location: Chr2:181387762-181459426 bp, - strand  Genetic Position: Chr2, 103.63 cM, cytoband H4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  EDJ22 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2, which encodes the start codon and the BTB domain of the zinc finger and BTB domain, with an enhanced green fluorescent protein followed by a polyadenylation signal and a floxed neo cassette. Microarray analysis confirmed the absence of transcript expression in dendritic cells. Cre-mediated recombination removed the floxed neo cassette. (J:184205)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zbtb46 Mutation:  21 strains or lines available
References
Original:  J:184205 Satpathy AT, et al., Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med. 2012 Jun 4;209(6):1135-52
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory