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Tg(Lck-Ppp3ca*)28Naka
Transgene Detail
Nomenclature
Symbol: Tg(Lck-Ppp3ca*)28Naka
Name: transgene insertion 28, Toshinori Nakayama
MGI ID: MGI:5635497
Synonyms: dnCN Tg
Transgene: Tg(Lck-Ppp3ca*)28Naka  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Lck-Ppp3ca*)28Naka expresses 1 gene
 
Mutation detailsThis transgene expresses a dominant negative mutated form of Ppp3ca under the control of the Lck proximal promoter. Sequence encoding five amino acid residues in the phosphatase active site (148-52) was deleted. Three transgenic lines were established. Line 28 expresses 50 copies of the transgene. (J:62700)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:62700 Yamashita M, et al., T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med. 2000 Jun 5;191(11):1869-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/20/2020
MGI 6.16
The Jackson Laboratory