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Kif21atm1.1Ece
Targeted Allele Detail
Nomenclature
Symbol: Kif21atm1.1Ece
Name: kinesin family member 21A; targeted mutation 1.1, Elizabeth C Engle
MGI ID: MGI:5635264
Synonyms: Kif21aKI
Gene: Kif21a  Location: Chr15:90933276-91049948 bp, - strand  Genetic Position: Chr15, 45.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213171
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 20 was replaced with one in which a point mutation (C to T) results in the amino acid substitution of tryphtophan for arginine at position 954 (R954W). Cre-mediated recombination removed the neomycin resistance cassette inserted into intron 19. (J:213171)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kif21a Mutation:  57 strains or lines available
References
Original:  J:213171 Cheng L, et al., Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Apr 16;82(2):334-49
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory