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Tnnt1tm1.2Jin
Targeted Allele Detail
Nomenclature
Symbol: Tnnt1tm1.2Jin
Name: troponin T1, skeletal, slow; targeted mutation 1.2, Jian-Ping Jin
MGI ID: MGI:5635256
Synonyms: ssTnT-KO, Tnnt1-exon 11-13 deletion
Gene: Tnnt1  Location: Chr7:4504569-4515975 bp, - strand  Genetic Position: Chr7, 2.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:219907
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted into intron 10 and intron 13. Cre-mediated recombination removed exons 11 through 13. The predicted truncated product mimicks the protein involved in Amish nemaline myopathy. A FRT-flanked neomycin resistance cassette was inserted into intron 10. Western blot analysis confirmed the absence of protein expression in the soleus muscle. (J:219907)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnnt1 Mutation:  1 strain or line available
References
Original:  J:219907 Wei B, et al., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue. J Physiol. 2014 Mar 15;592(Pt 6):1367-80
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory