Cdk6^tm1.1Mama
Targeted Allele Detail

Summary

• Symbol: Cdk6^tm1.1Mama
• Name: cyclin dependent kinase 6; targeted mutation 1.1, Marcos Malumbres
• MGI ID: MGI:5635037
• Synonyms: Cdk6^R
• Gene: Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
• Alliance: Cdk6^tm1.1Mama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218704
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 1 was replaced with a modified exon 1 in which nucleotide substitution (CGC to TGC) results in the amino acid substitution of cysteine for arginine at position 31 (R31C). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon. (J:218704)

Tumor Data

List all tumor models in MMHCdb carrying Cdk6^tm1.1Mama

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk6 Mutation: 39 strains or lines available

Notes

ES cell = ESER1.56 (strain of origin not specified)

References

• Original: J:218704 Rodriguez-Diez E, et al., Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood. 2014 Oct 9;124(15):2380-90
• All: 2 reference(s)