Nucks1^tm1.1Vter
Targeted Allele Detail

Summary

• Symbol: Nucks1^tm1.1Vter
• Name: nuclear casein kinase and cyclin-dependent kinase substrate 1; targeted mutation 1.1, Vinay Tergaonkar
• MGI ID: MGI:5634908
• Synonyms: Nucks^F
• Gene: Nucks1 Location: Chr1:131838272-131864059 bp, + strand Genetic Position: Chr1, 57.22 cM
• Alliance: Nucks1^tm1.1Vter page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211777
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 4. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 4 floxed. (J:211777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nucks1 Mutation: 68 strains or lines available

References

• Original: J:211777 Qiu B, et al., NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling. Cell Rep. 2014 Jun 26;7(6):1876-86
• All: 3 reference(s)