Gt(ROSA)26Sor^tm2(Ucn2)Jde
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2(Ucn2)Jde
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jan Deussing
• MGI ID: MGI:5634348
• Synonyms: R26^flopUcn2, UCN2-COE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2(Ucn2)Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220369
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm2(Ucn2)Jde expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ucn2 (MGI:2176375)

• Mutation details: Coding sequence for murine Ucn2 gene was preceded by a loxP-flanked transcriptional terminator and then was knocked into the Gt(ROSA)26Sor locus. Upon cre recombinase expression and excision of the loxP-stop sequence, the Ucn2 gene is predicted to be expressed. (J:220369)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1061 strains or lines available

References

• Original: J:220369 Spyroglou A, et al., Adrenal and Ovarian Phenotype of a Tissue-Specific Urocortin 2-Overexpressing Mouse Model. Endocrinology. 2015 Jul;156(7):2646-56
• All: 1 reference(s)