Mir34a^tm1.2Ayn
Targeted Allele Detail

Summary

• Symbol: Mir34a^tm1.2Ayn
• Name: microRNA 34a; targeted mutation 1.2, Alexander Yu Nikitin
• MGI ID: MGI:5629852
• Synonyms: mir-34a^KO
• Gene: Mir34a Location: Chr4:150152911-150153012 bp, + strand Genetic Position: Chr4, 80.85 cM
• Alliance: Mir34a^tm1.2Ayn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211711
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the microRNA. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette with a 3' loxP site inserted downstream of the microRNA. Cre-mediated recombination removed the microRNA sequence. (J:211711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir34a Mutation: 12 strains or lines available

References

• Original: J:211711 Cheng CY, et al., miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Rep. 2014 Mar 27;6(6):1000-7
• All: 1 reference(s)