Abcc8^tm2.1Jbry
Targeted Allele Detail

Summary

• Symbol: Abcc8^tm2.1Jbry
• Name: ATP-binding cassette, sub-family C member 8; targeted mutation 2.1, Joseph Bryan
• MGI ID: MGI:5629812
• Synonyms: Sur1^loxP
• Gene: Abcc8 Location: Chr7:45753952-45829441 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Abcc8^tm2.1Jbry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215008
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A loxP and FRT-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:215008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc8 Mutation: 75 strains or lines available

References

• Original: J:215008 Nakamura Y, et al., Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells. PLoS One. 2014;9(3):e91525
• All: 4 reference(s)