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Targeted Allele Detail
Symbol: Lrit3tm1Lex
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:5629558
Synonyms: Lrt3nob6
Gene: Lrit3  Location: Chr3:129787881-129804030 bp, - strand  Genetic Position: Chr3, 58.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:214644
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 were deleted and replaced by a betageo/puro cassette, with only 21 bp of exon 3 remaining. This was confirmed at the genomic and RNA level. The construct contains a premature stop codon in the first 8 bp of the selection cassette, which is predicted to lead to a truncated 206 amino acid protein lacking presumably the immunoglobulin-like (Ig-like), serine-rich, fibronectin III, transmembrane and PDZ-binding domains. (J:214644)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrit3 Mutation:  12 strains or lines available
Original:  J:214644 Neuille M, et al., Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). PLoS One. 2014;9(3):e90342
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory