Stk3^tm1Wtao
Targeted Allele Detail

Summary

• Symbol: Stk3^tm1Wtao
• Name: serine/threonine kinase 3; targeted mutation 1, Wufan Tao
• MGI ID: MGI:5629557
• Gene: Stk3 Location: Chr15:34875645-35155990 bp, - strand Genetic Position: Chr15, 14.34 cM, cytoband B3.3
• Alliance: Stk3^tm1Wtao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209448
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene followed by a neomycin resistance cassette was fused in frame with exon 5 and deleted exon 6. Western blot analysis confirmed the absence of protein expression in the kidney. (J:209448)

Tumor Data

List all tumor models in MMHCdb carrying Stk3^tm1Wtao

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk3 Mutation: 47 strains or lines available

References

• Original: J:209448 Du X, et al., Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. J Immunol. 2014 Feb 15;192(4):1525-35
• All: 7 reference(s)