Bcar1^tm1.2Alk
Targeted Allele Detail

Summary

• Symbol: Bcar1^tm1.2Alk
• Name: breast cancer anti-estrogen resistance 1; targeted mutation 1.2, Alex L Kolodkin
• MGI ID: MGI:5621193
• Synonyms: p130Cas^delta
• Gene: Bcar1 Location: Chr8:112437106-112470441 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Bcar1^tm1.2Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the low level presence of a truncated protein. (J:213067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcar1 Mutation: 27 strains or lines available

References

• Original: J:213067 Riccomagno MM, et al., Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
• All: 1 reference(s)