Prdm8^tm1.1Kmiz
Targeted Allele Detail

Summary

• Symbol: Prdm8^tm1.1Kmiz
• Name: PR domain containing 8; targeted mutation 1.1, Ken-ichi Mizutani
• MGI ID: MGI:5621000
• Gene: Prdm8 Location: Chr5:98315241-98335313 bp, + strand Genetic Position: Chr5, 47.77 cM, cytoband E3
• Alliance: Prdm8^tm1.1Kmiz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted into exon 2. Cre-mediated recombination in ES cells removes the selection cassette prior to insertion of an FRT-flanked neomyin resistance cassette with a 5' loxP site downstream of exon 5. Cre-mediated recombination removed exon 2 through 5. Western blot analysis confirmed the absence of protein expression in the brain. (J:212695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm8 Mutation: 21 strains or lines available

References

• Original: J:212695 Inoue M, et al., Prdm8 regulates the morphological transition at multipolar phase during neocortical development. PLoS One. 2014;9(1):e86356
• All: 1 reference(s)