Tg(Amelx-Mmp20)24Jdb
Transgene Detail

Summary

• Symbol: Tg(Amelx-Mmp20)24Jdb
• Name: transgene insertion 24, John D Bartlett
• MGI ID: MGI:5620383
• Transgene: Tg(Amelx-Mmp20)24Jdb Location: unknown
• Alliance: Tg(Amelx-Mmp20)24Jdb page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Amelx-Mmp20)24Jdb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mmp20 (MGI:1353466)

• Mutation details: The transgene vector was constructed so that mouse Mmp20 cDNA was placed between 4639 bp of the mouse amelogenin promoter and 1127 bp of amelogenin 3' non-coding region that included amelogenin polyadenylation sites. Founder 24 produced high levels of Mmp20 in incisors of mice that did not express the endogenous Mmp20 gene. (J:206207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:206207 Shin M, et al., Matrix Metalloproteinase-20 Over-Expression Is Detrimental to Enamel Development: A Mus musculus Model. PLoS One. 2014 Jan 23;9(1):e86774
• All: 1 reference(s)