Kdm6b^tm1.2Sdim
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.2Sdim
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.2, Stefanie Dimmeler
• MGI ID: MGI:5619798
• Synonyms: Jmjd3^-
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.2Sdim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: One loxp site was inserted in intron 3 and an FRT flanked neomycin selection cassette, together with a second loxP site, was inserted in intron 5. The neo selection cassette was subsequently removed by expression of flp recombinase. Exons 4 and 5 containing the ATG start site are thus flanked by loxP sites. Cre recombinase expression then excised the two floxed exons. (J:211228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 65 strains or lines available

References

• Original: J:211228 Ohtani K, et al., Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res. 2013 Sep 13;113(7):856-62
• All: 1 reference(s)