Atg16l1^tm1.1Xav
Targeted Allele Detail

Summary

• Symbol: Atg16l1^tm1.1Xav
• Name: autophagy related 16 like 1; targeted mutation 1.1, Ramnik Xavier
• MGI ID: MGI:5619350
• Synonyms: Atg16l1^T300A
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^tm1.1Xav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211028
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Single point mutation
• Mutation details: An A to G nucleotide change was introduced in codon 300 of exon 9. This caused a Threonine to Alaninee mutation. An FRT flanked neomycin resistance was also inserted downstream of exon 9. Subsequent flp recombinase expression excised the selection cassette. This mutation reduces the stability of the protein resulting in reduced steady state levels. (J:211028)

Expression

In Mice Carrying this Mutation:

51360 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 46 strains or lines available

Notes

ES cell line = BS20 (Brian Seed 20; derived from 129S1/SvImJ mice).

References

• Original: J:211028 Lassen KG, et al., Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6
• All: 11 reference(s)