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Gys1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Gys1tm1c(EUCOMM)Wtsi
Name: glycogen synthase 1, muscle; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5619172
Gene: Gys1  Location: Chr7:45434844-45456619 bp, + strand  Genetic Position: Chr7, 29.31 cM
Mutation
origin
Mutant Cell Line:  EPD0069_4_A05
Germline Transmission:  Earliest citation of germline transmission: J:218886
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_gt1
 
Mutation detailsThe L1L2_gt1 cassette was inserted at position 45441974 of Chromosome 7 upstream of the critical exons 6-8 (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exons 6-8 at position 45443868. The critical exons 6-8 are thus flanked by loxP sites. Flp mediated recombination created the "conditional ready" (floxed). Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:173534, J:218886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gys1 Mutation:  24 strains or lines available
References
Original:  J:218886 Duran J, et al., Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain. J Cereb Blood Flow Metab. 2013 Apr;33(4):550-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory