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Targeted Allele Detail
Symbol: Slc7a5tm1.1Daca
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; targeted mutation 1.1, Doreen A Cantrell
MGI ID: MGI:5618433
Synonyms: Slc7a5fl, Slc7a5-Flox
Gene: Slc7a5  Location: Chr8:122607885-122634425 bp, - strand  Genetic Position: Chr8, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:196444
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting vector contains loxP sites flanking exon 1, including the initiation codon. An FRT-flanked neomycin resistance (neo) cassette fused to an internal ribosomal entry site (IRES) and a splice donor (SD) sequence, followed by a third loxP site, are placed downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo-IRES-SD cassette. (J:213820)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc7a5 Mutation:  21 strains or lines available
Original:  J:196444 Sinclair LV, et al., Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 2013 May;14(5):500-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory