Ern1^tm1.1Yli
Targeted Allele Detail

Summary

• Symbol: Ern1^tm1.1Yli
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 1.1, Yong Liu
• MGI ID: MGI:5618267
• Synonyms: Ire1alpha^f
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm1.1Yli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210463
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:210463)

Generation of the Ern1^tm1.1Yli allele

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 58 strains or lines available

References

• Original: J:210463 Shao M, et al., Hepatic IRE1alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling. Nat Commun. 2014;5:3528
• All: 9 reference(s)