Skp2^tm1.1Lzhu
Targeted Allele Detail

Summary

• Symbol: Skp2^tm1.1Lzhu
• Name: S-phase kinase-associated protein 2; targeted mutation 1.1, Liang Zhu
• MGI ID: MGI:5618249
• Synonyms: Skp2^4A
• Gene: Skp2 Location: Chr15:9112073-9155512 bp, - strand Genetic Position: Chr15, 3.84 cM, cytoband A2
• Alliance: Skp2^tm1.1Lzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210319
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Four conserved leucines in the cyclin A binding domain between residues 40 and 60 were mutated to alanines and a floxed neo cassette was inserted into intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:210319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Skp2 Mutation: 47 strains or lines available

References

• Original: J:210319 Lu Z, et al., Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. Nat Commun. 2014;5:3463
• All: 1 reference(s)