Prss8^tm1.2Kkita
Targeted Allele Detail

Summary

• Symbol: Prss8^tm1.2Kkita
• Name: serine protease 8 (prostasin); targeted mutation 1.2, Kenichiro Kitamura
• MGI ID: MGI:5618163
• Synonyms: PRSS8^delta
• Gene: Prss8 Location: Chr7:127524889-127529266 bp, - strand Genetic Position: Chr7, 69.84 cM
• Alliance: Prss8^tm1.2Kkita page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210235
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted in intron 2 and a loxP site was inserted in intron 5 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 3- 5. (J:210235)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss8 Mutation: 23 strains or lines available

References

• Original: J:210235 Uchimura K, et al., The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling. Nat Commun. 2014;5:3428
• All: 2 reference(s)