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Sostdc1tm2Snd
Targeted Allele Detail
Nomenclature
Symbol: Sostdc1tm2Snd
Name: sclerostin domain containing 1; targeted mutated 2, Scott Sunders
MGI ID: MGI:5617945
Synonyms: Wise-
Gene: Sostdc1  Location: Chr12:36314169-36318452 bp, + strand  Genetic Position: Chr12, 16.82 cM, cytoband B2
Genetic correction of Wise with Lrp5 during ossification

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neoLacZ cassette containing stop codons at the 3' end was inserted into exon 1. For unknown reasons, the lacZ gene inserted into the locus is not expressed. (J:216098)
Generation of the Sostdc1tm1Snd and Sostdc1tm2Snd alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sostdc1 Mutation:  20 strains or lines available
References
Original:  J:216098 Ellies DL, et al., Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory