About   Help   FAQ
Targeted Allele Detail
Symbol: Sostdc1tm2Snd
Name: sclerostin domain containing 1; targeted mutated 2, Scott Sunders
MGI ID: MGI:5617945
Synonyms: Wise-
Gene: Sostdc1  Location: Chr12:36314169-36318452 bp, + strand  Genetic Position: Chr12, 16.82 cM, cytoband B2
Genetic correction of Wise with Lrp5 during ossification

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:216098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neoLacZ cassette containing stop codons at the 3' end was inserted into exon 1. For unknown reasons, the lacZ gene inserted into the locus is not expressed. (J:216098)
Generation of the Sostdc1tm1Snd and Sostdc1tm2Snd alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sostdc1 Mutation:  23 strains or lines available
Original:  J:216098 Ellies DL, et al., Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory