Cd1d1^tm1.2Rsb
Targeted Allele Detail

Summary

• Symbol: Cd1d1^tm1.2Rsb
• Name: CD1d1 antigen; targeted mutation 1.2, Richard S Blumberg
• MGI ID: MGI:5617734
• Synonyms: Cd1d1^-
• Gene: Cd1d1 Location: Chr3:86903141-86906748 bp, - strand Genetic Position: Chr3, 37.91 cM
• Alliance: Cd1d1^tm1.2Rsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210436
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 (at site 10310) and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 (at site 12190) via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2-4. PCR of a spontaneous mutation in the C57BL/6J Cd1d2 gene confirmed integration in the C57BL/6J allele. (J:210436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd1d1 Mutation: 36 strains or lines available

References

• Original: J:210436 Olszak T, et al., Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May 22;509(7501):497-502
• All: 1 reference(s)