Ptf1a^{tm1.1(Atoh1)Mhos}
Targeted Allele Detail

Summary

• Symbol: Ptf1a^{tm1.1(Atoh1)Mhos}
• Name: pancreas specific transcription factor, 1a; targeted mutation 1.1, Mikio Hoshino
• MGI ID: MGI:5617549
• Synonyms: Ptf1a^Atoh1
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^{tm1.1(Atoh1)Mhos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210443
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ptf1a^{tm1.1(Atoh1)Mhos} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Atoh1

• Mutation details: The open reading frame of the gene was replaced with a cDNA for Atoh1 and a floxed pgk-neo cassette. Cre mediated recombination removed the neo cassette. (J:210443)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 29 strains or lines available

References

• Original: J:210443 Yamada M, et al., Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons. J Neurosci. 2014 Apr 2;34(14):4786-800
• All: 1 reference(s)