Prkci^tm2Rfar
Targeted Allele Detail

Summary

• Symbol: Prkci^tm2Rfar
• Name: protein kinase C, iota; targeted mutation 2, Robert V Farese
• MGI ID: MGI:5617537
• Synonyms: PKC-lambda KO
• Gene: Prkci Location: Chr3:31049893-31106889 bp, + strand Genetic Position: Chr3, 14.65 cM
• Alliance: Prkci^tm2Rfar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216249
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A mutation was generated by inserting a neomycin selection cassette into a Sal I restriction site, which was introduced into the second exon by site-directed mutagenesis. This insertion abrogates the transcription of the gene. (J:216249)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkci Mutation: 69 strains or lines available

References

• Original: J:216249 Sajan MP, et al., PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol. 2014 Jul;28(7):1097-107
• All: 1 reference(s)