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Targeted Allele Detail
Symbol: Krastm1Dsa
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Dieter Saur
MGI ID: MGI:5616879
Synonyms: FSF-KrasG12D
Gene: Kras  Location: Chr6:145216699-145250239 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:218155
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA codon 12 Glycine to aspartic acid mutation was engineered in exon 2. An FRT flanked stop codon with a splice acceptor 3' of the first FRT recombination site and a promoterless neomycin resistance cassette were introduced into the first intron. (J:218155)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  37 strains or lines available
Original:  J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory