Kras^tm1Dsa
Targeted Allele Detail

Summary

• Symbol: Kras^tm1Dsa
• Name: Kras proto-oncogene, GTPase; targeted mutation 1, Dieter Saur
• MGI ID: MGI:5616879
• Synonyms: FSF-KrasG12D
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm1Dsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Glycine codon 12 in exon 2 was changed to aspartic acid. An FRT site flanked STOP cassette with a splice acceptor 3' of the first FRT site and a promoterless neomycin resistance gene cassette were introduced into intron 1. (J:218155)

Tumor Data

List all tumor models in MMHCdb carrying Kras^tm1Dsa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 69 strains or lines available

References

• Original: J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7
• All: 21 reference(s)