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Tg(Tcra,Tcrb)2Litt
Transgene Detail
Nomenclature
Symbol: Tg(Tcra,Tcrb)2Litt
Name: transgene insertion 2, Dan R Littman
MGI ID: MGI:5616429
Synonyms: 7B8Tg
Transgene: Tg(Tcra,Tcrb)2Litt  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra,Tcrb)2Litt expresses 2 genes
 
Mutation detailsClone 7B8 was derived from a screen for TCR hybridomas prepared from TH17 intestinal CD4+ T cells responding to fecal material from segmented filamentous bacteria (SFB)-monoassociated mice. The receptor recognizes SFB epitope FSGAVPNK. CDR3 Vbeta14 (AWSRSPSQNTLY) and Valpha15 (AEGNMGYKLT) TCR sequences associated with the clone were introduced to vectors that enable transcription under the control of the natural TCRalpha and -beta promoter/enhancer elements. (J:212833)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:212833 Yang Y, et al., Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 2014 Jun 5;510(7503):152-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory