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Transgene Detail
Symbol: Tg(Tcra,Tcrb)2Litt
Name: transgene insertion 2, Dan R Littman
MGI ID: MGI:5616429
Synonyms: 7B8Tg
Transgene: Tg(Tcra,Tcrb)2Litt  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Tcra,Tcrb)2Litt expresses 2 genes
Mutation detailsClone 7B8 was derived from a screen for TCR hybridomas prepared from TH17 intestinal CD4+ T cells responding to fecal material from segmented filamentous bacteria (SFB)-monoassociated mice. The receptor recognizes SFB epitope FSGAVPNK. CDR3 Vbeta14 (AWSRSPSQNTLY) and Valpha15 (AEGNMGYKLT) TCR sequences associated with the clone were introduced to vectors that enable transcription under the control of the natural TCRalpha and -beta promoter/enhancer elements. (J:212833)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:212833 Yang Y, et al., Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 2014 Jun 5;510(7503):152-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory