Adam15^tm2.1Bbl
Targeted Allele Detail

Summary

• Symbol: Adam15^tm2.1Bbl
• Name: ADAM metallopeptidase domain 15; targeted mutation 2.1, Carl P Blobel
• MGI ID: MGI:5616076
• Synonyms: Adam15E>A
• Gene: Adam15 Location: Chr3:89246947-89257589 bp, - strand Genetic Position: Chr3, 39.07 cM
• Alliance: Adam15^tm2.1Bbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: The targeting vector is designed to insert a E to A point mutation into the catalytic domain (exon 11) by site-directed mutagenesis. An FRT-flanked neomycin cassette is inserted downstream of exon 11. The mutation results in a A to C change at nucleotide 6829 altering the corresponding amino acid from glutamate to alanine. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:217858)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam15 Mutation: 36 strains or lines available

References

• Original: J:217858 Maretzky T, et al., Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15. Invest Ophthalmol Vis Sci. 2014 Oct;55(10):6774-82
• All: 1 reference(s)