Myo6^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Myo6^m2Btlr
• Name: myosin VI; mutation 2, Bruce Beutler
• MGI ID: MGI:5615724
• Synonyms: torticollis
• Gene: Myo6 Location: Chr9:80072313-80219011 bp, + strand Genetic Position: Chr9, 43.98 cM
• Alliance: Myo6^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition at base pair 80,288,217 (v38) on chromosome 9, or base pair 123,242 in the GenBank genomic region NC_000075 within the donor splice site of intron 26. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 209-nucleotide exon 26 (out of 33 total exons), resulting in a frame-shift and coding of two aberrant amino acids followed by a premature stop codon after amino acid 888. (J:217799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo6 Mutation: 90 strains or lines available

References

• Original: J:217799 SoRelle J, et al., Mutagenetix entry for torticollis. MGI Direct Data Submission. 2015
• All: 1 reference(s)