Prkcb^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkcb^M2Btlr
• Name: protein kinase C, beta; mutation 1, Bruce Beutler
• MGI ID: MGI:5615710
• Synonyms: Tigris
• Gene: Prkcb Location: Chr7:121888327-122233625 bp, + strand Genetic Position: Chr7, 65.75 cM
• Alliance: Prkcb^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion at base pair 122,424,977 (v38) on chromosome 7, or base pair 135,898 in the GenBank genomic region NC_000073. The mutation corresponds to residue 444 in the mRNA sequence NM_008855 within exon 3 of 17 total exons. The mutation results in a histidine (H) to leucine (L) substitution at position 75 (H75L). (J:217791)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcb Mutation: 37 strains or lines available

References

• Original: J:217791 Wang KW, et al., Mutagenetix entry for Tigris. MGI Direct Data Submission. 2015
• All: 1 reference(s)