Plcg2^tm1.1Fdba
Targeted Allele Detail

Summary

• Symbol: Plcg2^tm1.1Fdba
• Name: phospholipase C, gamma 2; targeted mutation 1.1, Facundo Batista
• MGI ID: MGI:5615439
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^tm1.1Fdba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A 3.1kb fragment from the 3' end of a rat cDNA was fused to an EGFP followed by a polyadenylation signal. This was then fused to an EcoRI site in exon 8 of the mouse gene. A floxed neomycin cassette was inserted as well but subsequently excised from properly targeted mice. (J:133999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 73 strains or lines available

References

• Original: J:133999 Weber M, et al., Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med. 2008 Apr 14;205(4):853-68
• All: 1 reference(s)