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Gjb2tm1Kkam
Targeted Allele Detail
Nomenclature
Symbol: Gjb2tm1Kkam
Name: gap junction protein, beta 2; targeted mutation 1, Kazusaku Kamiya
MGI ID: MGI:5615096
Synonyms: Cx26f, Cx26flox
Gene: Gjb2  Location: Chr14:57336059-57342159 bp, - strand  Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209627
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsOne loxP site was introduced at the end of intron 1 and a neo cassette was introduced between two loxP sequences in exon 2. (J:209627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gjb2 Mutation:  22 strains or lines available
References
Original:  J:209627 Kamiya K, et al., Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Apr 1;124(4):1598-607
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory