Gjb2^tm1Kkam
Targeted Allele Detail

Summary

• Symbol: Gjb2^tm1Kkam
• Name: gap junction protein, beta 2; targeted mutation 1, Kazusaku Kamiya
• MGI ID: MGI:5615096
• Synonyms: Cx26^f, Cx26^flox
• Gene: Gjb2 Location: Chr14:57336059-57342159 bp, - strand Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
• Alliance: Gjb2^tm1Kkam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209627
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was introduced at the end of intron 1 and a neo cassette was introduced between two loxP sequences in exon 2. (J:209627)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjb2 Mutation: 21 strains or lines available

References

• Original: J:209627 Kamiya K, et al., Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Apr 1;124(4):1598-607
• All: 2 reference(s)