Ripk3^tm2Vmd
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm2Vmd
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 2, Vishva M Dixit
• MGI ID: MGI:5614606
• Synonyms: Ripk3^D161N
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm2Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209137
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A GAT to AAT mutation was inserted in exon 4 resulting in the replacement of aspartic acid at position 161 by asparagine (p.D161N). (J:209137)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 31 strains or lines available

References

• Original: J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
• All: 8 reference(s)