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Targeted Allele Detail
Symbol: Ripk3tm1Arte
Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, TaconicArtemis
MGI ID: MGI:5614565
Synonyms: Ripk3LSL
Gene: Ripk3  Location: Chr14:55784995-55788857 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:209137
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
Mutation detailsA GAT to AAT mutation was inserted in exon 4 resulting in the replacement of aspartic acid at position 161 by asparagine (D161N). A loxP-Stop-loxP (LSL) transcription termination cassette was inserted in intron 3. The LSL cassette can be removed via cre-mediated recombination which results in expression of the D161N mutant allele. (J:209137)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk3 Mutation:  22 strains or lines available
Original:  J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory