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Targeted Allele Detail
Symbol: Mirc10tm1Mtm
Name: microRNA cluster 10, including Mir15b through Mir16-2; targeted mutation 1, Michael McManus
MGI ID: MGI:5614202
Synonyms: miR-15b/ miR-16-2
Gene: Mirc10  Location: Chr3:69009772-69009996 bp  Genetic Position: Chr3, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:181752
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert an FRT site followed by a lacZ gene, a loxP site, a neomycin cassette, an FRT site and a loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) upstream of the microRNA stem loop and one loxP site immediately downstream of the microRNA stem loop. (J:181752)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mirc10 Mutation:  4 strains or lines available
Original:  J:181752 Park CY, et al., A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012;1(4):385-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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