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Kcnip2tm1Jmn
Targeted Allele Detail
Nomenclature
Symbol: Kcnip2tm1Jmn
Name: Kv channel-interacting protein 2; targeted mutation 1, Jeanne Nerbonne
MGI ID: MGI:5613711
Gene: Kcnip2  Location: Chr19:45792346-45816422 bp, - strand  Genetic Position: Chr19, 38.75 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214199
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 4 through 9, eliminating the majority of the C-terminal core domain. Western blot analysis confirmed the absence of protein expression in the brain. (J:214199)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnip2 Mutation:  5 strains or lines available
References
Original:  J:214199 Foeger NC, et al., Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents. J Physiol. 2013 Sep 1;591(Pt 17):4149-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory