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Hdac2tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Hdac2tm1Lex
Name: histone deacetylase 2; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:5613704
Gene: Hdac2  Location: Chr10:36974544-37001889 bp, + strand  Genetic Position: Chr10, 19.44 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214041
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ and neomycin resistance cassette replaced exons 2 through 5. Enzymatic activity confirmed a reduction in class I HDAC activity in the retina. (J:214041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:  27 strains or lines available
References
Original:  J:214041 Fan J, et al., Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci. 2013 Jun;54(6):4072-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory